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However, Zanaflex, when administered with food, the plasma concentration rises by 30% to one hour and 25 minutes. In a fasting state, the peak plasma concentration is one hour after ingestion & a half-life of about two hours. In the fasting state, the peak plasma concentrations. The half-life of Zanaflex is not influenced by food, but it does affect the peak plasma concentration. With a half-life varying between 20 to 40 hours, the metabolites of Zanaflex are not known to be active. The half-life of the drug is about two hours to two and a half. Hence, a single dose of the medication will take approximately 80-90 hours to get out of the system completely. .After taking either a tablet or capsule of Zanaflex, the peak plasma concentrations occur an hour after ingestion. The half-life of Zanaflex is approximately 2.5 hours, but its metabolites have a half-life of about 20 hours to 40 hours. The active ingredient in Zanaflex is Tizanidine and is used in treating antispastic in multiple sclerosis and spinal cord injury. ( Kaddar, N., Vigneault, P., Pilote, S., Patoine, D., Simard, C. While oral administration of the drug, it is completely absorbed. The complete impact of these actions is thought to alleviate the simplification of spinal motor neurons. The effects of the medication are most remarkable on the polysynaptic pathways. Zanaflex is a central alpha-2-adrenergic receptor agonist & it reduces the spasticity by increasing the presynaptic inhibition of motor neurons. With more than 8 million prescriptions, it was the 86th most commonly prescribed medication in the United States in 2018.

Zanaflex is available as a generic medication. The drug was approved by FDA in 1996 in the United States for medical use. It can be used along with other medicines or alone too. The medication belongs to a class of drugs called Central Alpha-2-Adrenergic Agonist. Tizanidine, sold under the brand name Zanaflex, is a prescription medication used to treat the symptoms of muscle spasticity due to multiple sclerosis or spinal cord injury.
